Welcome to the Dayal lab

The Dayal lab investigates mechanisms of thrombosis under a variety of pathological conditions using sophisticated animal models and clinically relevant human samples. Specific research interests include thrombosis associated with aging, cardiovascular risk factors, infection and cancer.

Celebratory dinner for Shreyashree’s success at Comprehensive examination.

Dayal Lab at Internal Medicine Research Day


Thrombotic diseases such as myocardial infarction, stroke, deep vein thrombosis and pulmonary embolisms are the leading causes of morbidity and mortality worldwide. The primary focus of Dr. Dayal’s laboratory is to define the mechanisms of thrombosis using murine models and clinically relevant human specimens. We are currently funded to study risk factors such as aging, obesity, pre-diabetes, COVID-19 and cancer. A developing interest is also in studying thrombosis associated with hormonal therapy. We have established methods to conduct in vivo models of experimental thrombosis (for arterial as well as venous systems) in mice. We use assays to monitor ex vivo platelet activation, aggregation, and thrombi formation and in vivo thrombosis, and study mechanistic involvement of reactive oxygen species including mitochondria, and NETs (neutrophil extracellular traps), in thrombosis. A secondary interest is to investigate cognitive responses in aging. The Dayal laboratory is currently funded through the R01s from National Institute of Allergy and Infectious Diseases (NIAID, NIH) and Heart, Lung and Blood (NHLBI, NIH), VA Merit Award (CSRD), as well as through internal research funding.

The Lab

Dayal Group 2017

Principal Investigator

Postdoctoral Fellows

Research Assistant/Lab Manager

Undergraduate Student

Seminal Lab Publications


*Dayal S, Baumbach GL, Arning E, Bottiglieri T, Faraci FM, Lentz SRDeficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemiaPLoS One. 2017 Apr 17;12(4):e0175732. doi: 10.1371/journal.pone.0175732. eCollection 2017.


*Dayal S, Gu SX, Hutchins RD, Wilson KM, Wang Y, Fu X, Lentz SR. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arterioscler Thromb Vasc Biol. 2015;35(8):1798-804.


*Dayal S, Wilson KM, Motto DG, Miller FJ, Chauhan A, Lentz SR. Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. Circulation, 2013, 127(12):1308-16.


*Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci, FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood, 2012, 119(13):3176-83.


Chrissobolis S, Didion SP, Kinzenbaw D, Schrader LI, Dayal S, Lentz SR, Faraci FM. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension 2008;51:872-877.


Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and APP regulation. J. Neurosci. 2007:27:2751-2759


Dayal S, Wilson KM, Leo L, Arning E, Bottiglieri T, Lentz SR. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood 2006;108:2237-43.


Dayal S, Devlin AM, McCaw RB, Liu M, Arning E, Bottiglieri T, Shane B, Faraci FM, Lentz SR. Cerebral vascular dysfunction in methionine synthase deficient mice. Circulation 2005;112:737-744


Dayal S, Arning E, Bottiglieri T, Boger RH, Sigmund CT, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemia. Stroke 2004;35:1957-1962


Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow R, Sigmund CD, Heistad DD, Faraci FM, Lentz SR. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res 2001;88:1203-1209

Contact Information

Medical Laboratories
Medical Laboratories



3160 ML (Laboratory)
3186 ML (Office)

25 S Grand Ave
Iowa City, IA 52246

Medical Laboratories Map  | Directions