Seminal Lab Publications

• Pradeep A, Ramalho I, Carvour ML, Sivamurugan SM, Singh U, Comellas AP, Dayal S. Cardiovascular, Renal, and Pulmonary Risks of Long COVID: A Retrospective Cohort Study Stratified by Age and Sex. J Am Heart Assoc. 2026 Aug 20:e049226. doi: 10.1161/JAHA.126.049226. Epub ahead of print. PMID: 42622238.
• Palani Kumar MK, Iyer KS, Shahi SK, Raygoza Garay JA, Mangalam A, Dayal S. Age and sex dependent shift in murine gut microbiome reveals pathological links to host cardiovascular and metabolic pathways. Geroscience. 2026 Jun 5;. doi: 10.1007/s11357-026-02336-2. [Epub ahead of print] PubMed PMID: 42247160.
• Ahmed A, Yadav P, Jensen M, Geasland K, Swamy J, Spitz DR, Abel ED, Jalal D, Dayal S. Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes. J Clin Invest. 2026 Feb 16;136(4). doi: 10.1172/JCI195662. eCollection 2026 Feb 16. PubMed PMID: 41433113; PubMed Central PMCID: PMC12904718.
• Kozlova D, Gimblet C, Wendt L, Akbari S, Taiwo A, Dayal S, Ten Eyck P, Stanhewicz A, Trinity J, Jalal D. Vascular dysfunction is associated with major adverse cardiovascular events in prediabetes: A cohort study. PLoS One. 2025;20(6):e0324945. doi: 10.1371/journal.pone.0324945. eCollection 2025. PubMed PMID: 40471971; PubMed Central PMCID: PMC12140275.
• Eustes AS, Palani Kumar MK, Peterson JA, Mast AE, Lentz SR, Dayal S. Elevated tissue factor pathway inhibitor delays thrombin generation in COVID-19 but is not associated with clinical outcomes. Blood Vessel Thromb Hemost. 2025 Aug;2(3):100071. doi: 10.1016/j.bvth.2025.100071. eCollection 2025 Aug. PubMed PMID: 40765912; PubMed Central PMCID: PMC12320461.
• Reader BF, Rosas L, Knopf BA, Liu Y, Alzate-Correa D, Bhat A, Carey A, Cuervo AM, Dayal S, Demarco RS, Elliehausen CJ, Englund DA, Hamilton HL, Johnston M, Kang P, Konopka AR, Lepola N, Presley CJ, Schafer MJ, Serrano J, Singer BD, Song MA, Stanford KI, Taylor J, Wei W, Yeh CY, Zhang L, Zhang L, Anderson RM, Bai H, Robbins PD, Lamming DW, Mihaylova MM, Rojas M, Mora AL. The Fifth Annual Symposium of the Midwest Aging Consortium. J Gerontol A Biol Sci Med Sci. 2025 Jan 16;80(2). doi: 10.1093/gerona/glae296. PubMed PMID: 39704343; PubMed Central PMCID: PMC11772560.
• Ahmed A, Patil G, Sonkar VK, Jensen M, Streeter J, Dayal S. Loss of endogenous Nox2-NADPH oxidase does not prevent age-induced platelet activation and arterial thrombosis in mice. Res Pract Thromb Haemost. 2024 Oct;8(7):102597. doi: 10.1016/j.rpth.2024.102597. eCollection 2024 Oct. PubMed PMID: 39582807; PubMed Central PMCID: PMC11585761.
• Eustes AS, Ahmed A, Swamy J, Patil G, Jensen M, Wilson KM, Kudchadkar S, Wahab A, Perepu U, Miller FJ Jr, Lentz SR, Dayal S. Extracellular histones: a unifying mechanism driving platelet-dependent extracellular vesicle release and thrombus formation in COVID-19. J Thromb Haemost. 2024 Sep;22(9):2514-2530. doi: 10.1016/j.jtha.2024.05.019. Epub 2024 May 28. PubMed PMID: 38815756; PubMed Central PMCID: PMC11343660.
• Aleman M, Arepally GM, Baglin T, Buitrago L, Davizon-Castillo P, Dayal S, Flick MJ, Gerber G, Hisada Y, Kolev K, O'Loghlen A, Rezaie AR, Sparkenbaugh EM, Stavrou EX, Ünlü B, Vercellotti GM. Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina. Res Pract Thromb Haemost. 2024 Mar;8(3):102395. doi: 10.1016/j.rpth.2024.102395. eCollection 2024 Mar. PubMed PMID: 38699410; PubMed Central PMCID: PMC11063502.
• Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG. The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury. Redox Biol. 2024 Apr;70:103022. doi: 10.1016/j.redox.2023.103022. Epub 2024 Jan 1. PubMed PMID: 38215546; PubMed Central PMCID: PMC10821164.
• Kumar R, Patil G, Dayal S. NLRP3-Induced NETosis: A Potential Therapeutic Target for Ischemic Thrombotic Diseases? Cells. 2023 Nov 26;12(23). doi: 10.3390/cells12232709. Review. PubMed PMID: 38067137; PubMed Central PMCID: PMC10706381.
• *Dayal S, Baumbach GL, Arning E, Bottiglieri T, Faraci FM, Lentz SR. Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. PLoS One. 2017 Apr 17;12(4):e0175732. doi: 10.1371/journal.pone.0175732. eCollection 2017.
• *Dayal S, Gu SX, Hutchins RD, Wilson KM, Wang Y, Fu X, Lentz SR. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arterioscler Thromb Vasc Biol. 2015;35(8):1798-804.
• *Dayal S, Wilson KM, Motto DG, Miller FJ, Chauhan A, Lentz SR. Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. Circulation, 2013, 127(12):1308-16.
• *Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci, FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood, 2012, 119(13):3176-83.
• Chrissobolis S, Didion SP, Kinzenbaw D, Schrader LI, Dayal S, Lentz SR, Faraci FM. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension 2008;51:872-877.
• Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and APP regulation. J. Neurosci. 2007:27:2751-2759.
• Dayal S, Wilson KM, Leo L, Arning E, Bottiglieri T, Lentz SR. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood 2006;108:2237-43.
• Dayal S, Devlin AM, McCaw RB, Liu M, Arning E, Bottiglieri T, Shane B, Faraci FM, Lentz SR. Cerebral vascular dysfunction in methionine synthase deficient mice. Circulation 2005;112:737-744.
• Dayal S, Arning E, Bottiglieri T, Boger RH, Sigmund CT, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemia. Stroke 2004;35:1957-1962.
• Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow R, Sigmund CD, Heistad DD, Faraci FM, Lentz SR. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res 2001;88:1203-1209.